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The enzymes AMPK and SIRT1 are the silent conductors of your metabolism.

Many people immediately think of calories and digestion when they hear the word “metabolism”. But metabolism is much more than that: it is the control center for energy, health, well-being and even the way you age.

If you can stimulate your metabolism, you will take your body to a new level – with more power, better blood sugar balance, a clearer head, fewer cravings and a natural lightness in everyday life.

When your metabolism is functioning optimally, it regulates your energy levels, burns excess fat, stabilizes blood sugar levels, reduces silent inflammation and promotes cell regeneration.

All of this happens quietly in the background – as long as your body gets what it needs. And that is often no longer the case these days.

Why your metabolism is often slowed down

Our modern way of life is at odds with our biology: too little exercise, too much sitting, constant snacking, lack of sleep, stress and environmental toxins take their toll. Your cells become unbalanced – and important metabolic processes slow down. As a result, you feel tired, heavy, irritable or constantly hungry – despite a healthy diet or exercise.

There are two real key players in your body that decide whether your metabolism is active or in energy-saving mode.

The inner switches to stimulate the metabolism: AMPK and SIRT1

Two enzymes are at the heart of cellular metabolic control:
AMPK (AMP-activated protein kinase) and SIRT1 (sirtuin 1).
They can be thought of as highly intelligent control centers that trigger the following processes when activated:

Energy production in the mitochondria (your cellular power plants)
Fat burning and glucose utilization
Cell repair, cleansing and regeneration
Anti-inflammatory and antioxidant protection
Protection against premature cell ageing

AMPK is often referred to as the “master regulator of energy metabolism” because it is activated when there is a lack of energy and then efficiently utilizes cellular energy sources such as glucose and fatty acids.

SIRT1 is considered a “longevity enzyme” that activates cell protection in fasting and stress situations, regulates inflammation and even influences epigenetic processes – i.e. which genes are active.

AMPK and SIRT1 are like the silent conductors of your metabolism: while AMPK recognizes when energy is needed and ignites the turbo, SIRT1 ensures cell protection, balance and healthy ageing. Together, they bring your metabolism back into an active, regenerative state – without any fasting or extreme training.

In short: if you want to stimulate your metabolism sustainably and profoundly, you need to activate AMPK and SIRT1.

When does the body activate AMPK and SIRT1 on its own?

The two enzymes AMPK and SIRT1 normally only switch on when your body reports a real “biological need” – e.g. through:

  • Physical activity

  • Fasting or low-calorie phases

  • Cold stimuli or heat stress (sauna etc.)

  • Acute cellular stress

From an evolutionary point of view, this made sense: only in phases of physical activity or food shortages was it essential for survival to use energy efficiently and ramp up repair mechanisms.

Today, on the other hand, we live in a state of constant abundance. The result: AMPK and SIRT1 fall asleep. And this is precisely one of the main reasons why many people do not notice any results despite eating healthily or exercising.

Care300® – natural bio-activator to stimulate the metabolism

Care300® is a patented, clinically tested organic mango raw material from the Totapuri mango(Mangifera indica L.). Scientific studies have shown that it can increase the activity of AMPK by over 50 % and simultaneously activate SIRT1.

This means that Care300® acts like a natural stimulant that helps your body to rev up your metabolism – without you having to fast or exercise for hours on end.

How Care300® stimulates your metabolism – scientifically proven:

AMPK activation by +50 % – more energy, better glucose uptake, effective fat burning

  • SIRT1 stimulation – cell protection, anti-inflammation, anti-ageing
  • Improved blood glucose regulation – demonstrably lower fasting values and HbA1c (long-term blood glucose)
  • Higher insulin sensitivity – the cells react better to insulin again, sugar is utilized more effectively
  • Better vascular function after meals – indicating more responsive metabolic control

These effects were demonstrated in a clinical double-blind study with 75 men and women (43-70 years) who took 300 mg Care300® daily. Significant improvements in the most important metabolic markers were seen after just 4 weeks.

Stimulate your metabolism – without fasting, without compromise

Care300® is therefore a completely new approach to stimulating the metabolism holistically and gently – on a cellular level and based on sound science. The bioactive plant substances contained in the mango activate precisely those mechanisms that are often blocked by our lifestyle.

For you this means:

  • Less cravings
  • More energy in everyday life
  • Active fat burning
  • More stable blood sugar
  • Fewer inflammatory processes
  • Healthier ageing

Give your metabolism the activation it deserves

If you feel tired, sluggish, unbalanced or lacking in energy – even though you are doing “everything right” – then it is time to stimulate your metabolism in a targeted way. Care300® gets the central energy processes of your cells going again – without extreme diets or deprivation.

Buchwald-Werner, Sybille et al. “Effects of Mangifera indica (Careless) on Microcirculation and Glucose Metabolism in Healthy Volunteers.” Planta medica vol. 83,10 (2017): 824-829. doi:10.1055/s-0043-103017

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