Hyaluronic acid capsules – Do they really work? All about benefits, studies and what you should look out for.
Hyaluron capsules – the beauty molecule for skin & joints
Hyaluronic acid is one of the most sought-after active ingredients in skin care and joint health. It is known to bind large amounts of water and thus keep skin, connective tissue and joints supple. In addition to creams and serums, hyaluronic acid capsules are becoming increasingly popular as they have a systemic effect and not just a superficial one. But are they really more effective? What are the differences in application? And what should you look out for when buying them? In this article, you will find out everything you need to know about hyaluronic acid capsules.
What is hyaluronic acid and how does it work in the body?
Hyaluronic acid is a naturally occurring sugar molecule found throughout the body. Its main function is to bind water, playing a crucial role in skin hydration, tissue elasticity and joint lubrication. Hyaluronic acid levels are particularly high at a young age, but decrease steadily with age. As a result, the skin loses its elasticity, joints become more susceptible to wear and tear and dry eyes occur more frequently. This is precisely where hyaluronic acid capsules come in to supply the body with this essential substance from within.
The benefits of hyaluronic acid

Hyaluronic acid offers numerous health benefits for the skin, joints and general well-being:
- Moisture retention: Binds large amounts of water and keeps skin and tissue hydrated.
- Anti-aging effect: Supports skin elasticity, reduces wrinkles and gives a youthful appearance.
- Joint health: Promotes the gliding ability of the joints and can alleviate symptoms of osteoarthritis.
- Support of the connective tissue: Strengthens tendons, ligaments and the supporting tissue of the skin.
- Promotes wound healing: Accelerates the healing process of skin injuries.
- Protection against oxidative stress: Can protect the skin from free radicals and environmental damage.
- Relieves dry eyes: Helps stabilize the tear film and reduces eye dryness.
- Supports oral and dental health: promotes the moisture of the mucous membranes in the mouth.
What science says about the effect of hyaluronic acid capsules
The effect of orally ingested hyaluronic acid has been well studied scientifically – especially with regard to its effects on skin health.
A randomized, placebo-controlled double-blind study showed that a daily intake of 120 mg hyaluronic acid over 12 weeks could significantly improve skin hydration and visibly reduce wrinkles(PubMed). Another clinical study also confirmed that a noticeable improvement in skin hydration was achieved after just 4-8 weeks(PubMed).
With regard to joint health, most of the positive results currently come from studies on hyaluronic acid injections directly into the joint, for example for osteoarthritis. There are still few conclusive studies available on the effect of orally ingested hyaluronic acid on the joints – further research is needed here(PubMed Central).
In summary, it can be said that taking hyaluronic acid capsules orally can do the skin in particular noticeable good, while the effect on joints is promising but should be investigated further.
High molecular weight vs. low molecular weight hyaluronic acid – which is better?
The natural hyaluronic acid in the human body has a molecular size between 2,500 kDa and 10,000 kDa, which makes it significantly larger than many forms used in cosmetics or food supplements. This large molecular structure ensures long-lasting moisture retention, but is also the reason why it cannot penetrate deep into the skin in its natural form.
High-molecular hyaluronic acid (>1,000 kDa) remains as a cosmetic product in the upper layers of the skin, where it forms a protective barrier that retains moisture. When used internally in the form of hyaluronic acid capsules, it is particularly suitable for joint lubrication and long-term moisturizing of the skin from the inside, as it is broken down slowly and therefore has a longer effect.
Low-molecular hyaluronic acid (<500 kDa), on the other hand, can penetrate deeper layers of the skin from the outside as a cosmetic product and be absorbed more quickly. Although it is effective, it is metabolized more quickly and therefore has a shorter duration of action.
The ideal choice depends on the desired effect. If you want long-term results for joints and skin, you should opt for high-molecular hyaluronic acid. Low-molecular variants can be useful in cosmetic products in combination with other active ingredients to provide specific areas of the skin with additional moisture from the outside.
Production of hyaluronic acid - where does it really come from?
Animal hyaluronic acid (cockscomb)
In this traditional method, hyaluronic acid is extracted from the cockscombs of poultry. The tissue is mechanically crushed, enzymatically broken down and then purified using various filtration processes. The resulting hyaluronic acid has a high molecular weight, but the quality can vary greatly. This method is also ethically problematic and unsustainable, as it is based on factory farming.
Hyaluronic acid from bacterial fermentation
This modern method relies on genetically modified bacteria, usually Streptococcus equi, which produce hyaluronic acid in a controlled fermentation process. The bacteria are cultivated in nutrient solutions, where they release hyaluronic acid as a metabolic product. This is then isolated from the solution, purified and dried. The problem here is the frequent use of genetic engineering, which raises ethical concerns. In addition, chemical residues from the production process cannot always be avoided.
Plant-based hyaluronic acid (Tremella fungus, GreenIuronic)
A particularly sustainable and ethically safe method is extraction from the Tremella mushroom. This fungus naturally contains hyaluronic acid with a high bioavailability. It is extracted using hot water extraction, followed by a filtration and drying process. GreenIuronic uses this method to offer a purely plant-based and environmentally friendly alternative that is characterized by high purity and effectiveness.
Hyaluronic capsules vs. serums and creams – what really works?
Hyaluron is not only available in capsule form, but also in creams and serums. However, there are big differences in the effect:
Hyaluronic capsules vs. serums & creams – what really works?
Criterion | Creams & serums (external application) |
Hyaluron capsules (internal use) |
Mode of action | Superficial moisture binding, short-term effect | Systemic effect via the bloodstream |
Long-term effect | No | Yes |
Influence on joints & connective tissue | No | Yes |
Depth of hydration | Limited effect on upper skin layers | Moisturizing from the inside out |
Ethical sustainability | Dependent on ingredients | High for vegan capsules (e.g. GreenIuronic) |
Why hyaluronic capsules are the better choice
Hyaluronic acid capsules offer a decisive advantage over serums and creams, as they work from the inside out and supply the entire body with moisture. While serums and creams only moisturize the upper layers of the skin and offer a temporary smoothing effect, capsules have a systemic effect. They reach deeper layers of the skin, joints, connective tissue and eyes via the bloodstream, where they contribute to long-term regeneration. They also support the body’s own hyaluronic acid production, which sustainably improves hydration. Another plus point is the ease of use – while serums and creams need to be applied several times a day, capsules only need to be taken regularly to ensure an even supply.
Conclusion
If you want to maintain healthy skin and joints in the long term, there is no way around a targeted supply of hyaluronic acid. While serums and creams only have a superficial effect, hyaluronic acid capsules offer a comprehensive supply of moisture from within. It is particularly important to choose the right hyaluronic acid. GreenIuronic’s plant-based origin, high bioavailability and ethically safe production make it the best choice for anyone who values quality and sustainability.
In these Ogaenics products you will find GreenIuronic® hyaluronic acid in organic quality
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Walker, Kendra, et al. “Hyaluronic Acid.” StatPearls, StatPearls Publishing, July 3, 2023.
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Iaconisi GN, Lunetti P, Gallo N, Cappello AR, Fiermonte G, Dolce V, Capobianco L. “Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications-A Comprehensive Review.” Int J Mol Sci. 2023 Jun 18;24(12):10296. doi: 10.3390/ijms241210296. PMID: 37373443; PMCID: PMC10299688.
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Hsu, Tzu-Fang et al. “Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study.” Nutrients vol. 13,7 2220. 28 Jun. 2021, doi:10.3390/nu13072220
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Gao YR, Wang RP, Zhang L, Fan Y, Luan J, Liu Z, Yuan C. “Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test.” Skin Res Technol. 2023 Nov;29(11):e13531. doi: 10.1111/srt.13531. PMID: 38009035; PMCID: PMC10661223.
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- Bravo, Bruna et al. “Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence.” Dermatologic therapy vol. 35,12 (2022): e15903. doi:10.1111/dth.15903
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Santilli, Valter et al. “Hyaluronic acid in the management of osteoarthritis: injection therapies innovations.” Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases vol. 13,2 (2016): 131-134. doi:10.11138/ccmbm/2016.13.2.131